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More than 1 in 5 Americans between the ages of 40 and 75 take a statin to prevent an initial heart attack or stroke, a 2017 study estimated. Still there are some people for whom statins don't work or Who can't take a high dose because they experience side effects such as stomach problems or muscle aches. Even with diet, exercise and statins, it's estimated nearly 15 million patients in the US cannot get to the recommended cholesterol levels, according to the company.

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